GABA
"Studies Show A 550% Increase
In Growth Hormone Levels With Just 5 Grams Of GABA!"
Product Information
GABA, Gamma Aminobutyric Acid, is an amino acid classified
as a neurotransmitter (A neurotransmitter is a substance
that transmits nerve impulses across a synapse. A
synapse is a region where nerve impulses are transmitted
across axon terminals.) Studies have shown GABA to
play a key role in the secretion of Growth Hormone.
The principle anabolic actions of Growth Hormone include
the stimulation of amino acid transport, stimulation
of protein synthesis and the proliferation of cell
growth.
GABA’s
high concentration in the hypothalamus suggests this
amino acid plays a significant role in hypothalamic-pituitary
function. The hypothalamus is a region of the posterior
section of the brain and is the regulating center
for visceral (instinctive) functions such as sleep
cycles, body temperature, and the activity of the
pituitary gland.
The
pituitary gland is the master endocrine gland effecting
all hormonal functions of the body. One primary hormone
of concern to the athlete is growth hormone (GH) and
its various hormonal constituents.
The
amino acid GABA has been shown in numerous studies
to promote significant increases in plasma growth
hormone levels.
There
have been literally hundreds of clinical studies on
GABA and numerous studies on GABA’s ability to elevate
growth hormone levels. As with most nutritional studies,
GABA research has come directly from the medical community.
One noted study from the First Medical Clinic at the
University of Milan in Milan, Italy titled, "Effect
of acute and repeated administration of gamma aminobutyric
acid (GABA) on growth hormone and prolactin secretion
in man", shows just how effective GABA is.
Quoted
results from this study showed "In all of the 19 subjects
studied, compared with 18 controls, plasma growth
hormone levels were significantly increased (above
5 ng/ml) by acute oral administration of 5 g of GABA."
This
study showed over a 5 1/2 fold increase in plasma
growth hormone levels 90 minutes after GABA administration.
That is a significant increase unmatched by any other
nutritional means.
Most
cited studies on amino acids and growth hormone elevation
utilize intravenous delivery means. This is unrealistic
and doesn’t reflect real world results. Studies on
GABA have been performed with both oral and intravenous
administration with the oral route showing remarkable
effectiveness.
GABA’s
growth hormone elevating effects rival that of potent
pharmaceutical compounds.
References
1. Involvement of growth hormone-releasing factor
in growth hormone secretion induced by gamma-aminobutyric
acid in conscious rats. Murakami Y, 1985 Endocrinology
117(2), 787-789 (1985)
2.
Evidence for a GABAergic control of the exercise-induced
rise in GH in man. Steardo L, Iovino M, Monteleone
P, Agrusta M, Orio F Eur J Clin Pharmacol 28 (5):
607-609 (1985)
3.
Growth hormone secretion of the neonatal rat pituitaries
is stimulated by gamma-aminobutyric acid in vitro.
Acs Z, Makara GB, Stark E Life Sci 34 (16): 1505-1511
(Apr 1984)
4.
Gamma aminobutyric acid (GABA), a modulator of anterior
pituitary hormone secretion by hypothalamic and pituitary
action. McCann SM, Vijayan E, Negro-Vilar A, Mizunuma
H, Mangat H Psychoneuroendocrinology 9 (2): 97-106
(1984)
5.
Effect of gamma-aminobutyric acid on growth hormone
and prolactin secretion in man: influence of pimozide
and domperidone. Cavagnini F, Benetti G, Invitti C,
Ramella G, Pinto M, Lazza M, Dubini A, Marelli A,
Muller EE J Clin Endocrinol Metab 51 (4): 789-792
(Oct 1980)
6.
Effects of some gamma-aminobutyric acid (GABA)-ergic
drugs on the dopaminergic control of human growth
hormone secretion. Koulu M, Lammintausta R, Dahlstrom
S J Clin Endocrinol Metab 51 (1): 124-129 (Jul 1980)
7.
Effect of acute and repeated administration of gamma
aminobutyric acid (GABA) on growth hormone and prolactin
secretion in man. Cavagnini F, Invitti C, Pinto M,
Maraschini C, Di Landro A, Dubini A, Marelli A Acta
Endocrinol (Copenh) 93 (2): 149-154 (Feb 1980)
"A
single oral dose of 5 g gamma aminobutyric acid (GABA)
was given to 19 subjects and serial venous blood samples
were obtained before and 3 h after drug administration.
A placebo was administered to 18 subjects who served
as controls. GABA caused a significant elevation of
plasma growth hormone levels (P less than 0.001),
but did not consistently alter plasma prolactin concentration
since only 5 out of 15 subjects showed an increase
of the hormone. Eight additional subjects were submitted
to an insulin tolerance test before and after per
os administration of 18 g GABA daily for 4 days. Protracted
GABA treatment significantly blunted the response
of growth hormone and enhanced that of prolactin to
insulin hypoglycaemia (P less than 0.01). These results
indicate that pharmacological doses of GABA affect
growth hormone and prolactin secretion in man. The
precise nature of GABA's effects as well as its mechanism
of action remains to be clarified."
8.
Growth hormone release by gamma-aminobutyric acid
(GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB)
in the rat. Abe H, Kato Y, Chihara K, Ohgo S, Iwasaki
YEndocrinol Jpn 24 (2): 229-231 (Apr 1977)
9.
Regulation of growth hormone secretion Kato Y, Chihara
K, Daigo S, Iwasaki Y, Abe H Horumon To Rinsho 25
(2): 131-141 (Feb 1977)
10.
Pharmacological evidence for a dual GABAergic regulation
of growth hormone release in humans. Steardo L, Iovino
M, Monteleone P, Agrusta M, Orio F Life Sci 39 (11):
979-985 (Sep 1986)
11.
Involvement of alpha-adrenergic and GABAergic mechanisms
in growth hormone secretion induced by central somatostatin
in rats. Murakami Y, Kato Y, Koshiyama H, Inoue T,
Ishikawa Y, Imura H Brain Res 407 (2): 405-408 (Mar
1987)
12.
Evidence for a sex difference in the basal growth
hormone response to GABAergic stimulation in humans.
Monteleone P, Maj M, Iovino M, Steardo L Acta Endocrinol
(Copenh) 119 (3): 353-357 (Nov 1988)
13.
Role of hypothalamic factors (growth-hormone-releasing
hormone and gamma-aminobutyric acid) in the regulation
of growth hormone secretion in the neonatal and adult
rat. Acs Z, Lonart G, Makara GB Neuroendocrinology
52 (2): 156-160 (Aug 1990)
14.
Possible mediation of GABA induced growth hormone
secretion by increased calcium-flux in neonatal pituitaries.
Acs Z, Zsom L, Makara GB Life Sci 50 (4): 273-279
(1992)
15.
Potent agonists of growth hormone-releasing hormone.
II. Zarandi M, Serfozo P, Zsigo J, Deutch AH, Janaky
T, Olsen DB, Bajusz S, Schally AV Pept Res 5 (4):
190-193 (Jul 1992)
16.
New Gaba-containing analogues of human growth hormone-releasing
hormone (1-30)-amide: I. Synthesis and in vitro biological
activity. Mezo I, Kovacs M, Szoke B, Szabo EZ, Horvath
J, Makara GB, Rappay G, Tamas J, Teplan I J Endocrinol
Invest 16 (10): 793-798 (Nov 1993)
17.
Neuroendocrine regulation of growth hormone secretion
in sheep. VII. Effects of GABA. Spencer GS, Berry
CJ, Bass JJ Regul Pept 52 (3): 181-186 (Aug 1994)
18.
Growth hormone secretion and activation of cyclic
AMP by growth hormone releasing hormone and gamma-aminobutyric
acid in the neonatal rat pituitary. Mergl Z, Acs Z,
Makara GB Life Sci 56 (8): 579-585 (1995)
Label
Information
Servings per container: 33
Serving size: 3 Scoops
Amount per serving:
| Gamma
Aminobutyric Acid |
3
g |
Recommended
use
For adults only. As a dietary supplement, take three
to five grams mixed with 8 ounces of water or juice
approximately 30 minutes before sleep.
Warning(s)
GABA is a naturally occuring amino acid classified
as a neutrotransmitter. Some individuals may experience
a minor tingling of the skin and/or slight shortness
of breath shortly after taking GABA. This is characteristic
of this amino acid and quickly subsides.
AST
Sport Science selectively imports GABA under rigid
quality control conditions. Each batch is HPLC Certified
and Laboratory Tested for purity and potency.
Made
in USA
Copyright
2002 CLF Distribution Ltd. | 
